Begin typing your search above and press return to search.
proflie-avatar
Login
exit_to_app
election commmission
access_time 22 Nov 2024 4:02 AM GMT
Champions Trophy tournament
access_time 21 Nov 2024 5:00 AM GMT
The illness in health care
access_time 20 Nov 2024 5:00 AM GMT
The fire in Manipur should be put out
access_time 21 Nov 2024 9:19 AM GMT
America should also be isolated
access_time 18 Nov 2024 11:57 AM GMT
Munambam Waqf issue decoded
access_time 16 Nov 2024 5:18 PM GMT
DEEP READ
Munambam Waqf issue decoded
access_time 16 Nov 2024 5:18 PM GMT
Ukraine
access_time 16 Aug 2023 5:46 AM GMT
Foreign espionage in the UK
access_time 22 Oct 2024 8:38 AM GMT
exit_to_app
Homechevron_rightLifestylechevron_rightHealthchevron_rightDiabetes drug...

Diabetes drug effective on Covid 19 lung inflammation: Study

text_fields
bookmark_border
Diabetes drug effective on Covid 19 lung inflammation: Study
cancel

Metformin, an anti-diabetes drug, has been found to be effective to curb Covid-19 severity and mortality. The medicine used for bringing down blood sugar levels can prevent pulmonary or lung inflammation, the main factor in the severity of Covid 19.

Researchers at the University of California San Diego, along with a multi-institution subordinate team, could identify the molecular mechanism for the anti-inflammatory activity of metformin, commonly prescribed for Type 2 diabetes. The medicine lowers glucose production in the liver, thereby improving the body's response to insulin. Researchers have also observed that metformin contains properties that work against inflammation.

The scientist monitored a mouse suffering from acute respiratory distress syndrome (ARDS), which constitutes a life-threatening condition due to fluid leakage in the lungs. Such a leakage leads to difficulty in breathing and restricts oxygen supply to essential organs. ARDS, which is triggered by trauma and bacterial or viral infections, is a recurrent cause of the death of hospitalised Covid-19 patients.

According to the findings published online in the journal Immunity, administering metformin to mice before or after exposure to bacterial endotoxin, a surrogate for bacterial pneumonia, inhibited ARDS onset and lessened its symptoms. Metformin also produced a marked reduction in mortality in endotoxin-challenged mice and inhibited IL-1beta production and inflammasome assembly within alveolar macrophages, which are immune cells found in the lungs.

IL-1beta and IL-6, small proteins called cytokines, and their amounts are often highly elevated in persons infected by SARS-CoV-2, creating "cytokine storms" in which the body starts attacking its cells and tissues.

Production of IL-1beta depends on a large protein complex called the inflammasome, whose presence in lung tissue is found to be highly increased in deceased Covid-19 patients, researchers said. They also indicated metformin's therapeutic possibility for treating several neurodegenerative and cardiovascular diseases in which inflammasome activation is a factor.

Show Full Article
TAGS:Covid UpdatesDiabetes
Next Story