Begin typing your search above and press return to search.
proflie-avatar
Login
exit_to_app
Adani and his group buying governments
access_time 23 Nov 2024 6:53 AM GMT
Trump
access_time 22 Nov 2024 2:47 PM GMT
election commmission
access_time 22 Nov 2024 4:02 AM GMT
Champions Trophy tournament
access_time 21 Nov 2024 5:00 AM GMT
The illness in health care
access_time 20 Nov 2024 5:00 AM GMT
The fire in Manipur should be put out
access_time 21 Nov 2024 9:19 AM GMT
DEEP READ
Munambam Waqf issue decoded
access_time 16 Nov 2024 5:18 PM GMT
Ukraine
access_time 16 Aug 2023 5:46 AM GMT
Foreign espionage in the UK
access_time 22 Oct 2024 8:38 AM GMT
exit_to_app
Homechevron_rightLifestylechevron_rightHealthchevron_rightCancer cells may elude...

Cancer cells may elude chemotherapy: Study

text_fields
bookmark_border
cancel
camera_alt""

New York: According to a new study published in the journal 'Cancer discovery', cancer cells can escape chemotherapy by a process similar to senescence which is a type of "active hibernation", explaining why cancers recur after treatment.

Senior author Ari M Melnick of Weill Cornell Medicine said, "Acute myeloid leukaemia can be put into remission with chemotherapy, but it almost always comes back, and when it does, it's incurable."

Patient's samples of acute myeloid leukaemia (AML) tumours were extracted and used in organoids and mice models for the research. The study revealed that when AML cells undergo chemotherapy, a subset of the cells reaches a state of hibernation, causing a condition similar to inflammation. The wound healing process ensues because the cells seem similar to those injured, with most of their functions shut down.

Research informs that a protein named ATR is behind this inflammatory senescent state, and to prevent cancer cells from adopting this condition, one could block ATR.

The researchers texted the hypothesis in labs and confirmed that an ATR inhibitor could be administered to leukaemia cells to prevent them from entering senescence, thereby enabling chemotherapy to kill all the cells effectively.

Show Full Article
TAGS:HealthCancer
Next Story