Researchers in India identify 114 genetic variations linked to oral cancer

In studies conducted jointly by the Institute of Bioinformatics and Applied Biotechnology and the HCG Cancer centre, 114 genetic variants associated with human oral cancer have been identified.

Researchers have also discovered key genetic signatures that can predict survival in oral cancer patients, according to a study published in the journal Frontiers in Oncology.

Moreover, the analysis of mutations found 35 oncogenes, 11 tumour suppressor genes, and 2 DNA damage-repair genes associated with 114 unique genes.

Cancers of the mouth and gums account for 40% of all cancer cases in the country, with significant morbidity and mortality rates.

Oral cancer recurs in as many as 50 percent of cases, even after the most effective treatment.

In a statement, Prof. Vibha Choudhary from IBAB said A research would allow for an effective treatment that doesn't recur, and will enable precise treatment with an improved quality of life.

In addition, the researchers discovered novel mutations of the IRAK1 gene that may provide a means for providing target-directed treatments without harming healthy cells in the body.

The findings would guide towards cell-targeted personalised treatment, the researchers said.